TRANSFUSION MEDICINE Expression of ABO blood-group genes is dependent upon an erythroid cell–specific regulatory element that is deleted in persons with the Bm phenotype
نویسندگان
چکیده
1Department of Legal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; 2Cancer Chemotherapy Center and Hematology, University of Occupational and Environmental Health, Kitakyushu, Japan; 3Department of Legal Medicine, Shimane University School of Medicine, Izumo, Japan; 4Division of Medical Genetics and Biochemistry, Faculty of Medicine, University of Fukui, Eiheiji-cho, Japan; 5Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan; 6Department of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan; 7Japanese Red Cross Central Blood Institute, Tokyo, Japan; and 8Japanese Red Cross Tokyo Blood Center, Tokyo, Japan
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BACKGROUND AND OBJECTIVES An erythroid cell-specific regulatory element, referred to as the +5·8-kb site, had been identified in the first intron of the human ABO blood group gene. Subsequent studies revealed that either a 5·8-kb deletion including the +5·8-kb site or disruption of a GATA factor binding motif at the site was present in all Bm and ABm individuals examined. We investigated the mo...
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تاریخ انتشار 2012